Mourinho has made winning the FA Cup a priority for Spurs this season, but his side must up their game after being beaten 3-2 at home by Wolves at the weekend.
In truth, Spurs could have faced a tougher cup draw than Norwich - but the Canaries will have watched Wolves' victory at Tottenham Hotspur Stadium with interest.
Tottenham flagged as that game wore on and with the likes of Harry Kane and Heung-min Son injured, Mourinho will need a big performance.
Kick-Off: UTC 2020/03/04 19:45
Probable Lineups
Tottenham News
Lloris missed the Wolves defeat on Sunday with a groin injury, with Paulo Gazzaniga in line to keep his spot between the sticks.
Harry Kane, Moussa Sissoko, Son Heung-Min and Juan Foyth all miss the welcome of Norwich, but Ryan Sessegnon is back in full training.
Erik Lamela failed to make the bench at the weekend and is considered a doubt, while Troy Parrott, Tanguy Ndombele and Gedson Fernandes are among those pushing for starts.
Whoscored predicted result
Tottenham 3-2 Norwich