Napoli start Hirving Lozano, Dries Mertens and Lorenzo Insigne together in a return to 4-3-3, while Torino field Simone Verdi against his former club.
It kicks off at the Stadio Olimpico Grande Torino at 17.00 UK time (16.00 GMT).
Carlo Ancelotti has to do without suspended Kalidou Koulibaly, while Nikola Maksimovic and Mario Rui are injured, so Elseid Hysaj and Sebastian Luperto get rare starts.
The big change is the attack, where it looks like a return to 4-3-3 with Jose Callejon rested, so Chucky Lozano, Insigne and Mertens play together.
Torino are fresh from a 3-2 defeat to Parma and Gleison Bremer was sent off, so is banned today.
Soualiho Meite is dropped, Simone Zaza injured, with Diego Laxalt and Simone Verdi coming in.
Torino: Sirigu; Izzo, N’Koulou, Lyanco; Ansaldi, Baselli, Rincon, Lukic, Laxalt; Verdi, Belotti
Napoli: Meret; Di Lorenzo, Manolas, Luperto, Hysaj; Allan, Fabian, Zielinski; Lozano, Mertens, Insigne