41-year-old Andorra defender Ildefons Lima had to be substituted after pulling his hamstring while trying to keep up with England's Jadon Sancho.
Lima was brought on in the 31st minute as a replacement for Christian Garcia but then had to go off himself in the 63rd minute.
Sancho, who wasn't even born when Lima made his international debut in 1997, showed his speed and knocked the ball past his opponent.
Lima was left in agony and eventually had to go off.
Having represented his country 133 times, Lima is the most capped player in Andorra's history.
In addition, he has also scored eleven goals for Andorra, more than anybody else.
Commenting on the incident, one Twitter user wrote: 'That hurt just watching it'.
Another added: 'I wish I could've seen his face when he realised he needed to sprint at 160%.
'Hope he's ok tbf.'
Another wrote: 'My mate Lima the 41 year old has just pulled his hamstring trying to catch Sancho, not fair really!'.
England won the game 5-0 as they took another step towards securing qualification for the World Cup.
Ben Chilwell opened the scoreline, with Bukayo Saka, Tammy Abraham, James Ward-Prowse and Jack Grealish also finding the net.
Maccarthy001
482
I wish you speedy🏃♂️ recovery, just like the one you exhibited
steevojox
404
Isn't that Lingard laughing secretly in the corner? [Crylaugh]
epjo
289
SANCHO is the new CR7 without CR7 SANCHO should be in much pressure in MANCHESTER UNITED CR7 come to rescue the young CR7
BVN
153
CHILDREN OF THIS DAYS NO GET RESPECT AT ALL....