Arsenal duo Piero Hincapie and Martin Zubimendi have withdrawn from their respective national squads due to injury, leaving Mikel Arteta with a selection headache.
The Gunners have now had 10 players return to north London to receive medical treatment or assessment.
Hincapie left Ecuador's squad on Sunday, having played 72 minutes of their 1-1 draw against Morocco on Friday.
However, a statement released by Ecuador said the defender would return to Arsenal "to begin his recovery process" following medical tests, though details were not disclosed.
And shortly after, Spain confirmed Zubimendi had withdrawn from their squad for the upcoming game against Egypt.
The midfielder came off the bench to play 14 minutes in Spain's 3-0 win over Serbia on Friday, having replaced Rodri.
"Martin Zubimendi has withdrawn from the Spanish national team camp due to discomfort in his right knee," Spain said in a statement.
"To avoid any risk and to protect the player's health, he has been removed from the squad."
Hincapie is the fourth defender to withdraw for Arsenal, who also appear to have issues in midfield, with Zubimendi following Declan Rice, who left the England squad on Saturday, along with Bukayo Saka and Noni Madueke.
Arsenal are next in action in the FA Cup quarter-final against Southampton on Saturday, before a Champions League last-eight first leg against Sporting CP on April 7.
Pumacemptz
0
just trust the process, artetas masterclass , wants to take off attention from the team, and the rest, will be crowned champions, as we're going to in Ethiàd, COYG#
Widbiltz
0
This is a good sign that Arsenal will lose this season epl 🏆 to Manchester City, hallelujah 🙌
heeabkmsuy
0
only God knows
Salamot12
2
Ooh god help Arsenal with this injury
resabekpst
1
Fraudulent Arsenal and Arteta at wiork.UEFA should investigate them
Why, please note that Arteta does have the authority to select any players for international teams. Maybe it’s the international coaches trying to help keep their players fit for the World Cup. We have got a lot of games to play and we have players unavailable. It makes sense.
resabekpst
1
Arteta protecting his important players for the run in of remaining games of the premiership
Get away, but seriously you can’t blame him.
nimcdikuy
2
I'm not seeing arsenal winning any trophy this season 😂😂😅😅
resabekpst
1
this ia very bad
No mate international coaches are finally being fair to Arsenal. Not many players play without niggles. Also they are looking for squad players for the World Cup. Calafiori, Gyrolokes, Norgaard and loanee Kiwior. Are basically the ones who have got to play, for obvious reasons.
hanbcipuyz
0
No headache because we have better options and speedy recovery ❤️🩹 ✌🏿🤲🏿
Renabcdprs
0
Fraudulent Arsenal and Arteta at wiork.UEFA should investigate them
yeoclmosy
2
Arteta protecting his important players for the run in of remaining games of the premiership
Wocbmorsz
1
this ia very bad
Ubong12
0
The Mind Games, only for those who knows how this place works😂