Manchester United confirm Alexis Sanchez suffered a hamstring injury in training on Thursday and will require further tests to confirm its severity.
The 29-year-old sustained the injury in training on Thursday and will now be assessed ahead of the trip to St Mary's.
A club statement read: "Alexis sustained a hamstring injury in training on Thursday which requires further investigation to confirm severity."
Sanchez has struggled for first-team opportunities this season and was left out of the squad that beat Young Boys in the Champions League on Tuesday.
However, United manager Jose Mourinho expects the Chilean to remain at Old Trafford beyond the January window.
Speaking earlier this month, Mourino said: "He has never told me that he wants to leave. He never told me that he's not happy to stay.
"He is playing like the team. He is improving like the team is improving, when he plays he is giving us his personality.
"His desire is to play and to produce for the team and [he is] trying to adapt to the way we play and vice versa.
"Can he do better? We all can do better. I can do better, he can do better, all the players can do better."
Gabrieljackson
202
lol can't believe this guy earns 400 euros a week for doing nothing. me right now
EminenceBASIT
196
Sanchez why?
RealMd13
155
SHOULD ALEX GO BACK TO ARSENAL You left Arsenal for Man UNITED cuz of your arrogance THINKINg they were better than Arsenal but here we are and Arsenal Is DOING better than Man UNITED In The EPL and Its not to LATe to go back to ARSENAL and say sorry cuz I THInk they needs you more at Arsenal than at Man UNITED and I am not saYInG Arsenal sucks IM Just SAYING Sanchez Is more of Arsenal KInda player than Man UNITED #Red🔴devILs #Gunners 🔴🔴
Yussufnadara
123
Before and after Alex Sanchez