Wayne Rooney's Derby side produced a blistering start at Birmingham City.
Krystian Bielik, Graeme Shinnie with a penalty — Harlee Dean had fouled Louie Sibley — and Colin Kazim-Richards scored in the opening 26 minutes. Midfielder Jason Knight made it four on 77 minutes.
Sheffield Wednesday, who sacked boss Tony Pulis on Tuesday after only 10 games in charge following a disagreement on transfer policy, were in the hands of caretaker Neil Thompson at home to Middlesbrough.
Callum Paterson's calm finish on the half hour put Wednesday ahead and Liam Shaw made it two.
Boro's Duncan Watmore hit back but Wednesday seized a priceless 2-1 win.
Rotherham, playing on through a Covid crisis to avoid a points deduction, fell two down to Barnsley. Cauley Woodrow and Alex Mowatt struck but Michael Smith pulled one back.
Wycombe upset Cardiff 2-1, Ryan Tafazolli and David Wheeler scoring. Junior Hoilett replied late.
Burton Albion boss Jake Buxton is leaving the League One club after a 4-3 defeat at home by Wigan.
AndyFiindje
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Wayne on the pitch is beaten by Rooney off the pitch.