Chris Wilder has left Sheffield United following a review of last season when the team missed out on promotion to the Premier League in the play-off final.
An agreement is understood to be close for Ruben Selles to succeed Wilder at Bramall Lane following talks with the former Hull City manager.
Selles, who was sacked by the Tigers despite keeping them in the Championship, had previously been the manager of Reading and was interim boss at Southampton. The Spanish coach also beat Wilder's Blades 3-0 at Bramall Lane with Hull back in January.
The Blades won 90 points last season - a total which would have equalled their club record but for a two-point deduction imposed by the EFL - and that tally would have been enough to go up automatically in eight of the last 10 seasons.
After four successive defeats in the run-in, United were 15 minutes from victory at Wembley before two late goals saw Sunderland promoted instead.
Despite that near miss, the US-based consortium COH Sports, led by Steven Rosen and Helmy Eltoukhy, have decided they want to bring in a new head coach.
Gary O'Neil was under consideration for the role, but the Blades bosses have decided they want to go in a different direction. They completed a takeover last December, when Wilder was already in charge of the team.
Sheffield United said Wilder's achievements at the club would "never be forgotten" and that he and his coaches Alan Knill and Matt Prestridge depart "with the best wishes and gratitude of everyone".
Sky Sports News reported on Tuesday that there has been no rift with the board, and in fact Wilder has an excellent relationship with Rosen. The change in manager is motivated by the new regime wanting to bring in their own person to lead the football operation.
COH are determined to utilise a data-led approach to recruitment and play, which is something Wilder was open to following the takeover.
At the start of last season, Wilder was in charge during a huge rebuild, with 22 players leaving Bramall Lane and the average age of the squad coming down to 24. While it is thought the owners do recognise and appreciate how Wilder has added value to the squad, that has not been enough for him to keep his job.
Last week, United signed the Nigerian winger Ehije Ukaki from the Bulgarian club Botev Plovdiv based on his impressive statistics in the First Pro League.