The 19-year-old is currently on loan with RB Leipzig but is yet to make a senior appearance for them since his arrival from Chelsea
Speaking ahead of his side's Euro 2020 qualifier with Slovakia on Thursday, Giggs admitted that Ampadu, who has still been included in the latest selection for the October international break, should be playing more minutes to further his development and stay in the fold for his country.
“It is a concern because Ethan is at the age now where he has to play," the former Manchester United stalwart said.
“He’s had a few problems there injury-wise, nothing serious but little aches and pains. The last few camps he’s looked so much better in training.
“He is such a talent it’s hard to ignore. But it’s very difficult for him to play 90 minutes and back-to-back games, because he’s not had the minutes.”
The 45-year-old admitted that he had not spoken to Chelsea boss Frank Lampard over Ampadu's limited chances, but added that he intends to make a scouting trip to Germany soon.
Schalke winger Rabbi Matondo and St Pauli defender James Lawrence have also been named in recent squads by Giggs, with the former included for their latest double-header.
Speaking on the former's inclusion, the manager further backed stars to succeed away from the English game by following in the footsteps of Gareth Bale and Aaron Ramsey.
“Rabbi had an injury, then he had an infection into the injury,” he added. “It was a difficult time for him, but he scored his first goal the other week and he’s a talent.
“He’s at a big club and hopefully he will get a run of games there. The speed he’s got, he’s an option, whether starting or off the bench.
“We’ve got different scenarios abroad, with Ethan, Rabbi and James in Germany and Gareth and Aaron in Spain and Italy.
“It’s a different situation for players. You’ve seen it work with the likes of Jadon Sancho, who have done well abroad. I think it’ll happen more and more, but they’ve got to play.”