In what is a repeat of last summer's semi-final at the European Championship, Italy and Spain meet again, this time at the Stadio San Siro, in the Final Four of the Nations League. The Azzurri and La Roja will both be keen to win the match and advance to the final, where they will meet either France or Belgium. Stay with us for build-up to Italy vs Spain and then updates from the match itself.
Italy vs Spain LIVE SCORE: 0-0
This is the start of our live blog for Italy vs Spain. We'll have build-up and preview news here and then minute-by-minute updates once the ball gets rolling, with the entries nearest the top being the most recent.
16:45 BST: Italy vs Spain preview
There is a massive UEFA Nations League match taking place on Wednesday night, as Spain take on Euro 2020 winners Italy in Milan. The pair met at last summer's European Championship at the semi-final stage, where the Azzurri came away victorious on penalties.
The pair never fail to produce enthralling encounters and so often tend to meet on the big stage. With the Euro 2020 semi still fresh in the memory of both sets of fans, Wednesday's game promises to be both a fascinating technical and emotional duel.
Roberto Mancini and Luis Enrique still continue in their respective dugouts after the major tournament and, ahead of next year's World Cup in Qatar, this meeting is yet another chance for either coach to test out new players but also to test the squad in a high intensity match-up.
While it is far from as significant as a major tournament, both sides will want to clinch the silverware that's on offer, when facing either Belgium or France in the final. Here are all the details you need to know so you can watch and enjoy this match.
Italy vs Spain predicted line-ups
Italy's predicted line-up: Gianluigi Donnarumma; Giovanni Di Lorenzo, Leonardo Bonucci, Giorgio Chiellini, Emerson Palmieri; Nicolo Barella, Jorginho, Marco Verratti; Federico Chiesa, Lorenzo Insigne, Lorenzo Pellegrini.
Spain's predicted line-up: Unai Simon; Cesar Azpilicueta, Aymeric Laporte, Pau Torres, Sergio Reguilon; Koke, Sergio Busquets, Pablo Fornals; Ferran Torres, Mikel Oyarzabal, Pablo Sarabia.
Italy vs Spain: When does it start?
This is the big Wednesday night game, kicking off at 20:45 CEST. That's 19:45 BST for those in the UK, while the kick off time will be 14:45 EDT for those watching on from the east coast of the USA.
Italy vs Spain: Where to watch it?
Football fans in the United Kingdom can watch Italy vs Spain on Sky Sports on Wednesday night. Meanwhile, those in the USA can tune in through ESPN2, UniMas, TUDN, fuboTV, Sling Orange, Hulu + Live TV and Vidgo.