Giovani Lo Celso produced a miss of the season contender that forced Jose Mourinho to his knees in anguish.
The Spurs boss is having to make do without Harry Kane almost certainly for the rest of the season after he had surgery on his hamstring.
So there could not have been a worse time to face Jurgen Klopp's runaway Premier League leaders.
Roberto Firmino gave the visitors the lead in North London but it should have been 1-1 when Serge Aurier sent an 83rd-minute pass into the path of Lo Celso.
Somehow, inexplicably, unbelievably, the 23-year-old Argentina midfielder sent his virtual tap-in wide.
The miss was so bad it forced Mourinho - who had a selfie fail with a fan - to drop to his knees in disbelief and horror.
And social media users were left stunned too.
One wrote: "Lo Celso better sleep with his eyes open."
Another posted: "Jose set up brilliantly what can he do if Lo Celso misses from a yard. These people are determined to hate Mourinho."
One comment read: "Liverpool won the game but Mourinho's reaction after Lo Celso's miss won our hearts."
A fellow user wrote: "Mourinho falling to his knees after that Lo Celso miss is a meme waiting to happen."
Another wrote: "How in God's name did Lo Celso miss that opportunity? Mourinho's reaction says it all."
Firmino's goal puts Liverpool 16 points clear - and means the Reds have now set the record for the best ever start to a season in Europe's top five leagues.
It also means they are 38 games unbeaten and in with a great chance of matching Arsenal's legendary Invincibles season.
mzeereal
525
Mourinho players just killed him yesterday.. Lo Celso lose golden chance.. Lamela at 88minute wasted another golden chance in the penalty area dribbling himself instead of shooting or pass the ball.. Some players are very undetermined
ishti
412
To be fare to Mourinho, he had his Tactics spot on. They conceded a soft goal and missed few good chances. Specially the last half an hour were great for them. But Liverpool has learned to win when under pressure. So fair point.
Hamiklmps
402
who ever watch the game know spurs should win the game. son misses a golden oppurnityy and lo cleso too. Lo cleso and lamela change the tempo of the game once they in. Liverpool is having good luck . The thrown in should spurs have but liverpool got and score the goal. var is liverpool friends too. Enjoy it
jackson07
305
Mourinho set his team up brilliantly and if not for missed chances liverpool would have dropped maybe 2 or even all 3 points today