Manchester City won last season's Etihad derby 3-1 - but it was their first home win against their city rivals since 2014.
In fact United's record across the city has been good in recent years, two wins and a draw preceding last November's reverse.
Can they continue to keep their noisy neighbours quiet? We asked our Manchester United expert Samuel Luckhurst for his verdict.
Win, lose or draw?
United have an enviable big-game nous under Solskjaer but it is a tall order for them to clinch a second win against a top six team inside a week. United have not won consecutive league games since March and City looked more like themselves at Burnley, so probably a loss. Thepools.com certainly think so. They make City 1/3 while the away win is a huge 9/1.
First goalscorer?
Marcus Rashford has 12 in his last 13 for club and country and is the safe bet. He has scored more than double any other United teammate. He's a very, very big 9/1 to score first and 11/4 to notch any time.
Who's on the naughty step?
Ashley Young. He has already served a suspension for collecting five yellow cards this season and, whether it is Bernardo Silva or Raheem Sterling haring at him, odds are he will get booked. He should have been sent off at the Etihad the season before last, too.
Who's on pens?
Rashford, who broke his penalty pattern in midweek: scored, missed, scored, missed, scored, scored.
Will United keep a clean sheet?
No. They have kept just two in their last 26 in the league. Both Teams To Score is a solid 17/20 bet with thepools.com
Essein
222
always trust him in big games