Atalanta midfielder Mario Pasalic should start in Marten de Roon’s place against Ajax, when La Dea continue with Duvan Zapata and Luis Muriel up front.
The match kicks off at 20.00 UK time.
Gian Piero Gasperini’s men must bounce back from a 3-1 defeat to Sampdoria in Serie A, as Ajax visit Bergamo for the Orobici’s first game in the Champions League at the Gewiss Stadium.
The coach is expected to make only one change from the side who ran out 4-0 winners in Midtjylland last week, as Pasalic will replace injured De Roon.
He will be paired with Remo Freuler, as Rafael Toloi, Cristian Romero and Berat Djimsiti start at the back.
Hans Hateboer and Robin Gosens reclaim their places out wide, as Papu Gomez sits behind Colombian duo Zapata and Muriel.
Ajax arrive in a confident mood after a 13-0 win in the Eredivisie and Dusan Tadic is expected to be ready for another battle, supported by Antony and David Neres in a 4-3-3 formation.
Daley Blind could start in the middle, with Davy Klaassen and Ryan Gravenberch completing the midfield trident.
Andre Onana should start in goal as usual, with Noussair Mazraoui, Perr Schuurs, Lisandro Martinez and Nicolas Tagliafico in defence.
Atalanta (probable): Sportiello; Toloi, Romero, Djimsiti; Hateboer, Pasalic, Freuler, Gosens; Gomez; Zapata, Muriel
Ajax (probable): Onana; Mazraoui, Schuurs, Martinez, Tagliafico; Gravenberch, Klaassen, Blind; Antony, Tadic, Neres
Referee: Skomina (SLO)
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