Onana, Lukaku, De Cuyper, Lavia and Theate are not fit for the game against Israel and left the squad.
Belgium sit third in Nations League Group A2 following their 1-0 defeat to Italy on Thursday, a result that ended their hopes of reaching next year's quarter-finals.
They are simply playing to avoid automatic relegation when they face Israel behind closed doors in Hungary, with a draw enough to send the Red Devils through to a play-off against a third-placed finisher from League B.
Napoli striker Lukaku – Belgium's all-time leading scorer with 85 goals in 120 caps – has joined Aston Villa's Amadou Onana, Chelsea's Romeo Lavia, Arthur Theate of Eintracht Frankfurt and Brugge's Maxim De Cuyper in dropping out with unspecified issues.
Manchester City star Kevin De Bruyne had already asked not to be included in Domenico Tedesco's party as he works his way back to full fitness after suffering a thigh injury.
Sebastiaan Bornauw, Koni De Winter, Jeremy Doku and Youri Tielemans were also left out of Tedesco's squad due to fitness concerns, while uncapped Coventry City striker Norman Bassette has now been called up as cover.
chris_lamboo
120
5 goals in 5 Nations League games since September. Legend we love you
sheffayo
56
Nations League is the most useless and unnecessary tournament by Uefa. I wish they scrap it soonest 😞
Minsrama
47
They don’t want to be touched by pigs. 🐖 zionsts
Wocacdly
9
They don’t want to be touched by pigs. 🐖 zionsts
Stupid and very Silly of you to use such words which have on place in Sports.