Arsenal followed up their EFL Cup final loss by crashing out of the FA Cup at the quarter-final stage, with Shea Charles scoring the decisive goal in a stunning 2-1 win for Southampton.
Match Report
The Championship side took a deserved lead into half-time following Ross Stewart's prodded finish, but it looked like extra time would be required at St. Mary's after Viktor Gyokeres came off the bench to score Arsenal's equaliser.
However, Mikel Arteta's Premier League leaders never truly looked comfortable in defence and, after they lost Gabriel Magalhaes to an apparent knee injury, they were dealt a hammer blow by Southampton substitute Charles in the 85th minute, ending their hopes of a treble.
Gabriel Martinelli had a venomous effort headed behind by Taylor Harwood-Bellis, but Southampton did most of the early attacking through Leo Scienza, who had a penalty appeal waved away and failed to get a shot off after Gabriel's mistake allowed him in one-v-one.
Daniel Peretz was equal to Martin Odegaard's 20-yard blast, and the Arsenal skipper then skewed wide from a great position after being found by Martinelli a minute later.
Peretz also denied Max Dowman as Arsenal dialled up the pressure, but the Gunners still looked shaky defensively and they fell behind when Ben White misjudged James Bree's cross, granting Stewart time to take a touch before finishing past Kepa Arrizabalaga.
Southampton twice came close to doubling their lead early in the second half, with Tom Fellows rifling over and Scienza's ambitious curler bouncing off the top of the crossbar.
It looked as though the hosts would rue those near misses when Arsenal drew level in the 68th minute, with substitute Gyokeres steering Kai Havertz's pass into an empty net.
But after another excellent save from Peretz to frustrate Dowman, more sloppy play from the visitors was punished with five minutes to go, with Charles finishing off the inside of the post after another driving run from Fellows.
Martinelli and Noni Madueke missed half-chances to score Arsenal's second equaliser, and their ambitions for the season are now limited to just the Premier League and the Champions League, having been on for an unprecedented quadruple only two weeks ago.
Data Debrief: Southampton channel spirit of '76
Arsenal travelled to St. Mary's having progressed from 45 of their last 48 FA Cup ties against teams from outside the top flight, also winning 14 of their last 16 quarter-finals in the competition.
However, Arteta's side were coming off the back of a miserable defeat to Manchester City at Wembley, and their defence looked unnerved from the first whistle, with Stewart and Scienza repeatedly threatening in Southampton's left channel.
While the Gunners racked up 23 shots to Southampton's eight, they only narrowly edged the expected goals (xG) battle by 1.77 to 1.21, demonstrating their lack of penetration.
After beating Fulham in the fifth round, Southampton have now eliminated two top-flight teams in the same FA Cup campaign while outside of the top tier themselves for the first time since 1975-76, when they won the competition for the only time in their history.
The Saints wore a special yellow and blue shirt to mark the 50th anniversary of that historic triumph, and they can now dream of more Wembley glory after a famous win.
Match Events
0' The match is about to start!
3' No penalty for Southampton
7' Dowman's shot saved
10' Martinelli's shot saved by defender
18' Huge chance for Southampton!
25' Powerful shot from Odegaard
26' Big miss by Odegaard
30' Max Dowman fires in box
35' GOAL! Huge mistake fro Ben White! Southampton 1-0 Arsenal (Ross Stewart)
61' Highlight from Southampton vs Arsenal
62' Jesus, Lewis-Skelly, Odegaard ๐ Gyokeres, Calafiori, Madueke
63' Southampton hit the woodwork
68' GOAL! Viktor Gyรถkeres equalizes for gunner! Southampton 1-1 Arsenal
72' Gabriel ๐ Saliba
79' Havertz ๐ Zubimendi
83' Match Event for Southampton vs Arsenal
86' GOAL! Southampton 2-1 Arsenal
Line-ups
Southampton XI: Ryan Manning, James Bree, Ross Stewart, Finn Azaz, Peretz, Nathan Wood, Harwood-Bellis, Tom Fellows, Lรฉo Scienza, Cameron Bragg, Caspar Jander
Subs: Romeu, George Long, Cyle Larin, Cameron Archer, Samuel Edozie, Shea Charles, Joshua Quarshie, Jay Robinson, Nicholas Okeyunkle
Arsenal XI: Christian Nรธrgaard, Kepa, รdegaard, Jesus, Gabriel, Havertz, Ben White, Martinelli, Cristhian Mosquera, Lewis-Skelly, Max Dowman
Subs: David Raya, Viktor Gyรถkeres, Martรญn Zubimendi, Saliba, Madueke, Calafiori, Ceadach O'Neill, Marli Salmon, Andre Harriman-Annous
RyemisTricksin
668
From Quadruple to treble to double and it might end in trouble ๐ญ๐
Kidmoprstu
63
Arsenal had all their players on INJURY LIST. Whether it was by way of miracle or magic, they were all fit to play against Southampton ๐๐๐
AlwaysSoccer
53
Raise your hand if you are laughing at Arsenal...cause I know I am...
livingstoneDlam
37
same Arsenal, same story, same heartbreak ๐ ๐ข every season
aguillon
35
You can find every gif of nice goals here: https://www.matchgif.com/v2/live/matchGifs?match_id=54411696&language=en
Rame7
34
After Carabao we focus on the F.A, Champions League and Premier League. After the F.A we focus on the Champions League and Premier League after the Champions League we will focus on the end of the Premier League after the end of the Premier League we look forward to next season.
Hetcdmrstz
32
There goes another one . Quadruple to treble. Now from treble to trembling which looks like trouble!!!!
Binlause
24
Arsenal has ran out of Gus, this is the time where they usually Fumble season after season
KeamPen
23
Have you seen this guy anywhere?๐คฃ
Nam_So
18
Kwarlau
18
From Quadruple to treble to double and it might end in trouble ๐ญ๐
You made the best comment
Tabestz
17
Why I donโt see any arsenal fans here .is something something wrong ?๐ [Crylaugh][Crylaugh][Crylaugh][Crylaugh]
dinacelsz
16
NEW MOVIE | SPIDERMAN: Far from Trophy
kontext
15
From Quadruple to treble to double and it might end in trouble ๐ญ๐
they're not winning the ucl I can tell you that right now
JaybeeEmpire
12
from Quadraple to Treble to Double soon to be single ๐๐๐ then to absolutely nothing
Juyemnrsz
12
๐โฆ wwwwww, Arsenal will beat Chelsea on Semi Final, which Semi Final?๐๐
Joccdknory
10
Some Arsenal fans never play there mach they were thinking of how to beat Chelsea for semi final
Amalia4840
9
From Quadruple to treble to double and it might end in trouble ๐ญ๐
Definitely ๐๐คฃ
Cubabinory
7
Jesus Havertz, Ben White, Keppa , Madueke, we can't win anything with this bunch of useless players..we don't need them anymore with Arteta all out..
Hubdnopu
8
From Quadruple to treble to double and it might end in trouble ๐ญ๐
Singleple
fomadimory
8
From Quadruple to treble to double and it might end in trouble ๐ญ๐
you are evil
Wiycikltu
8
From Quadruple to treble to double and it might end in trouble ๐ญ๐
you nail it