Premier League players taking part in AFCON 2025 departed to join up with their national teams this week ahead of the tournament opener on Sunday, when hosts Morocco face Comoros.
The players called up could be absent for over a month, with the final of the tournament scheduled for January 18. So which Premier League clubs will be the most and least impacted?
Which clubs have the most players at AFCON?
A total of 32 Premier League players are taking part in the tournament, representing 14 of the 24 competing nations.
As shown in the graphic below, Sunderland are losing the most players with six. Their total is double that of any other Premier League club and the highest by any club across Europe's major leagues.
It includes two players who have played important roles defensively in holding midfielder Noah Sadiki and left-back Reinildo.
The pair have helped the Black Cats keep five clean sheets so far this season in the Premier League, the latest coming in Sunday's Wear-Tyne derby, during which they played the full 90 minutes.
Manchester United are losing three players in Bryan Mbeumo, Amad Diallo and Noussair Mazraoui, as are Fulham, in Alex Iwobi, Calvin Bassey and Samuel Chukwuemeze, and Burnley, in Lyle Foster, Hannibal Mejbri and Axel Tuanzebe.
Seven clubs are losing two players, including Manchester City, in Omar Marmoush and Rayan Ait-Nouri, with a further three clubs losing one player, including Liverpool in Mohamed Salah, who has departed having impressed off the bench against Brighton.
Leaders Arsenal are one of six Premier League clubs not losing any players to the tournament.
Which clubs are losing the most important players?
Losing players is one thing, losing important players is another.
In terms of minutes played by players taking part in AFCON, Sunderland again come out as the worst-hit.
Their six players called up to the tournament have played a combined 4,412 minutes in the Premier League this season. Sadiki and Reinildo account for around half that total, but Chemsdine Talbi and Bertrand Traore have also featured regularly.
Fulham are next on the list in second, narrowly ahead of Manchester United in third, as both teams lose players with just over 3,000 Premier League minutes played.
For the Cottagers, the biggest losses, in terms of minutes played, are Alex Iwobi and Calvin Bassey, both of whom represent Nigeria. For United, it's Cameroon's Mbeumo and Ivory Coast's Amad.
Everton and West Ham are next in the rankings, with Ndiaye, Idrissa Gueye, Malick Diouf and Aaron Wan-Bissaka all regular starters who have played more than 1,000 Premier League minutes this season.
Which clubs are losing the most attacking threat?
While Sunderland will have to cope without crucial defensive players, other clubs will have to manage without vital attackers.
Manchester United and Fulham are losing 11 goal involvements respectively with the departures of Mbeumo, Amad, Iwobi and Samuel Chukwueze.
Everton are next, losing eight, with six of them having come from Ndiaye, while Salah's involvement means Liverpool are losing seven, with the Egypt international having added his latest goal involvement with his assist off the bench in his last appearance before the tournament against Brighton.
Which clubs have the toughest fixtures during AFCON?
When ranking each club's next six Premier League fixtures, from now until the end of AFCON on January 18, based on league positions of their opponents, Aston Villa, who are not losing any players to the tournament, have the toughest schedule. Liverpool, without only Salah, have the easiest schedule.
Is Amorim's system switch due to AFCON?
The clubs most impacted by AFCON have of course had time to prepare knowing which of their players would likely feature at the tournament well in advance.
In Manchester United's case, did Monday's meeting with Bournemouth at Old Trafford hint at Amorim's plans?
He is losing two players key to his preferred system in Amad and Mbeumo, who occupy the right wing-back and right-sided No 10 spots respectively in his 3-4-2-1 formation.
But the 4-4 draw with Andoni Iraola's side, during which Amad and Mbeumo made their final appearances before the tournament, saw an unprecedented change of shape from the head coach.
For the first time at United, Amorim switched from a back three to a back four, a significant tactical adjustment which may be a response to losing Amad and Mbeumo for a busy run of fixtures.
How Amorim adapts is just one of many questions as Premier League clubs contend with their AFCON absentees.
Cshlord
0
please how do we place bet cos I placed 2 months bet away now and key players are not going to be involved...
Cukaknort
0
After all haters will still say man united don't sign Africa players
for the first time you talking 👄
lilmen20
0
bornamount nko?
StephenHassen
0
surprisingly Chelsea is not in the picture but has 55% of its starting line up as black pitched
to be honest when I saw the heading i thought we were top of the list
Wezabory
3
Man utd will be affected most as their key players will be out. The likes of Amad,Mazroui and Mbeumo. The worst thing is that they'll be playing Villa at an away match and you know how good villa is
yohkmnorsu
1
Manchester united bord can't you see now!! you will remember those players you sold stupid team
Bueilstu
1
we will with out african players
Feilds
0
injuries 🤕
Every team suffers injuries Sir ..
yocbeosuy
0
No excuses for NETFLIX FC Arsenal
injuries 🤕
yocbeosuy
0
If Arsenal didn't win this league then there is a problem... No excuses
bro injuries 🤕
JuBrown
1
Which African plays for man city
And Marmoush
Cezbcmnost
1
Which African plays for man city
Ait Nouri
nupdopsty
0
Which African plays for man city
nobacemory
2
They literally don’t have a single player from an African Nation. Black doesn’t mean African guys…
of course, I know, and no offence. I was just pointing the Irony. Chelsea is dominated by black players but non from Africa. There used to be 1. Didier 2. Mikel 3. Mendy 4. Etoo etc and Yes, am an African myself from Malawi and a chelsea fan
pisbckloz
1
surprisingly Chelsea is not in the picture but has 55% of its starting line up as black pitched
They literally don’t have a single player from an African Nation. Black doesn’t mean African guys…
pisbckloz
0
Chelsea should be on that list because some of there players are blacks
They literally don’t have a single player from an African Nation lol
shaffer12
1
After all haters will still say man united don't sign Africa players
MarioOnyeka
0
It is high time roben amorin change his formation
Gunnerneko
1
Arsenal hates African players, they chased Aubemayang and Thomas Partey
Since you were born 5 years ago go check Arsenal history of African players compared to your team. stupid comment
nobacemory
4
surprisingly Chelsea is not in the picture but has 55% of its starting line up as black pitched
akintayoibraheem
1
Let me hope you're not an African u idiot
I'm African100% bro
Zutacdkmr
0
excuses loading [Crylaugh]
rafaeljoel
0
this is the reason why every team don't want to sign African player...
Let me hope you're not an African u idiot
akintayoibraheem
0
this is the reason why every team don't want to sign African player...
faddkmpry
0
⚽
Nutacmntu
0
Sunderland could fall to upto 14 if they are not serious
RuggedEvangelist
1
Arsenal should know that most of their players are from Africa
RuggedEvangelist
3
Chelsea should be on that list because some of there players are blacks
Feilds
0
If Arsenal didn't win this league then there is a problem... No excuses
Exactly
Feilds
0
Manu right side is basically gone
😂
ice411
0
No excuses for NETFLIX FC Arsenal
Chaii Arsenal dn suffer 🤣🤣🤣
rutabcmos
4
🇨🇲 cameroon will take this one
secclmnyz
2
sads
yambcklrsu
1
Very good for City the away game against surprisingly Sunderland on 1st
Vaecimprst
1
Arsenal hates African players, they chased Aubemayang and Thomas Partey
Says a stupid fool
Vaecimprst
0
No excuses for NETFLIX FC Arsenal
Drunkards everywhere
Lovebug2
2
Arsenal hates African players, they chased Aubemayang and Thomas Partey
Rmulbah1992
3
THE VALUE OF AFRICAN PLAYERS IN EUROPE WILL BE FELT GREATLY.
Feilds
0
what has arsenal got to do with this?
They’re one of the least affected by AFCON
Zuucemos
0
No excuses for NETFLIX FC Arsenal
Lol if you look closely there are other clubs that are not loosing any player at all, they left them out and called them out, even when they are still on top😂😂😂😂😂😂😂😂😂😂😂. That’s definitely for a reason
IronU
5
If Arsenal didn't win this league then there is a problem... No excuses
hoydeklz
0
No excuses for NETFLIX FC Arsenal
what has arsenal got to do with this?
Voeenoprsz
1
Manu right side is basically gone
Ageerjok
0
No excuses for NETFLIX FC Arsenal
No excuses for Man Shity too
Feilds
2
No excuses for NETFLIX FC Arsenal