The Argentina star, who was watching from the stands, left when Isco scored his hat-trick.
Messi wasn't on the pitch for Argentina against Spain as he failed to overcome his hamstring niggles, with the Barcelona star watching from the VIP section of the Wanda Metropolitano alongside Lanzini.
But Messi's face fell as he watched Spain go on a scoring spree against his countrymen, and when Isco scored Spain's sixth (the Real Madrid man's hat-trick) Leo had had enough, standing up and walking out of the stands.
Busquets watching Spain destroy Argentina
Sergio Busquets was also in the VIP secion, alongside Fernando Hierro. He wasn't in the squad due to injury, but there's no doubt he's a starter for Lopetegui as one of Spain's key players.
Other big footballing names in the stands were former Spain coach Vicente del Bosque and Atlético Madrid manager Diego Simeone.
Abdik
131
Today was Isco's night. All the Spaniard players played well and they deserved victory. If Messi had played, maybe Argentina would have scored more but they cannot avoid defeat. Good luck both teams ✌
nuudeiz
92
k tan jst simple question messi alone bring all the fames n trophies to barca tan the same messi why he dn brng evn single fame n trophies to his own country......think b4 u talk be like [CR7] who brings fame n trophies to his clubs n country...i ll nt laugh bt who ever read tis ll feedback to u.
messi won under 20 world cup he was an Olympic medalist runner up world cup medal Ronaldo... apart from d euro, Portugal manage to win penalty against France where ronaldo only played for 15 mns due to injury.. at d end of d match ronaldo took all d glory pls who are we fooling
Mj - jnr
55
that moment when you realize that you have to retire from international football again during the world cup