Both the Belgian and Kyle Walker may be in doubt for Saturday's FA Cup showdown with Liverpool
Manchester City will be paying close attention to the fitness of Kevin De Bruyne following the inspirational midfielder's withdrawal in the second half of Wednesday's Champions League clash with Atletico Madrid.
De Bruyne came off just after the hour mark with City struggling to defend their slender 1-0 advantage from the first leg in the Wanda Metropolitano.
His club will hope he has escaped serious injury as they hope to continue fighting on multiple fronts in the final months of the 2021-22 season.
The Belgian pulled up in discomfort while on the run during the second half of the quarter-final second leg, just as Atletico began to push forward in their search for an equaliser.
He was unable to continue, and limped off as Raheem Sterling was brought in to replace him.
City were dealt a further blow minutes later when full-back Kyle Walker left the action due to injury.
Walker had clashed with Renan Lodi and despite receiving treatment was ultimately obliged to leave the field, replaced by Nathan Ake.
Now Pep Guardiola will hope neither of his key first-teamers has sustained lasting damage with a huge match on the horizon.
On Saturday City take on Liverpool in the semi final of the FA Cup, just a week after the Premier League high-fliers shared the points in an enthralling 2-2 that left the former at the top of the table by a single point.
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8
The people who are seeing Real Madrid like God are very wrong. Can you imagine conceiving 3 goals at home against Chelsea and u are thinking that Madrid is on fire? If you conceiving that from city, they will finish the game without u seeing any goals, and if you force it then you are gone with counter attack. Madrid is just being lucky they are the worst team in this champion league I watch all there match and I know what I saw less wait till the day.. this Madrid can’t beat any of city or Liverpool. Chelsea lost the game at home, and all the Goal were cheap one.