Phil Foden and Jude Bellingham have been recalled by England boss Thomas Tuchel for the November international break fixtures against Serbia and Albania.
Foden, who hasn't represented England since March, also earns a recall after an impressive recent upturn in form that scoring a brace in his most recent outing as Man City eased past Borussia Dortmund in the Champions League.
Bellingham returns after he was left out of Tuchel's last squad in October, despite the Real Madrid star saying he was fit and that he wanted to be called up.
Elsewhere, Bournemouth's Alex Scott has been handed his first call-up. The 22-year-old midfielder has represented England at youth level, winning the Euros with both the U19s and U21s.
Despite impressive displays so far this campaign, Brighton striker Danny Welbeck has not been included in the squad. However, Anthony Gordon, who was a doubt after his injury for Newcastle against Athletic Club in midweek, has been named.
Crystal Palace's Adam Wharton returns after missing out on England's last two squads, pulling out of the August selection due to injury.
There are no spots for Morgan Gibbs-White, Ruben Loftus-Cheek and Myles Lewis-Skelly, who have been omitted despite their involvement in October. Newcastle shotstopper Nick Pope replaces James Trafford.
Big headlines in Tuchel's latest squad
Sky Sports News' Rob Dorsett:
"This feels a really important announcement for Tuchel. There are only four matches before he has to name his World Cup squad. The feeling we had is if you're fit and playing for your club but not in this squad it's a long haul to make it into the World Cup squad.
"The big headlines: Foden in, Bellingham in. Both recalled, as we thought might be the case.
"Gibbs-White misses out at the expense of Foden.
"There's a real surprise call-up for Bournemouth midfielder Alex Scott. No one was talking about him. He's in for the first time under Tuchel - and so is Adam Wharton.
"Lewis-Skelly misses out. He's not playing an awful lot for Arsenal.
"Loftus-Cheek has been involved in the last couple of camps and misses out.
"And all that talk about Welbeck - no, it's not a recall for him after seven years out."
England's striking problem is up front
Sky Sports' Peter Smith:
"So many intriguing storylines to pick apart from this England squad announcement but amid the rotation of midfield options or No10 alternatives, one thing that jumps out at me is the strikers.
"Or, that should be striker. Because it's only Harry Kane.
"No Danny Welbeck but more eye-catching - no Ollie Watkins. He is struggling for form but his absence is significant.
"Marcus Rashford has of course, been used as a No 9 in the past but it's pretty clear he's better from the left and that's where he's thriving for Barcelona.
"Ivan Toney seems to have not impressed Tuchel when he was in previous camps, while Dominic Solanke's injury issues are limiting his prospects.
"Liam Delap has just returned from injury for Chelsea - and was swiftly sent off at Wolves - and I suspect he will be a long-term option.
"But right now, the cupboard looks pretty bare in regards to the centre forward position for England. A lot is resting on Kane staying fit and in form."
England squad in full:
Goalkeepers: Dean Henderson, Jordan Pickford, Nick Pope.
Defenders: Dan Burn, Marc Guehi, Reece James, Ezri Konsa, Nico O'Reilly, Jarrel Quansah, Djed Spence, John Stones.
Midfielders: Elliot Anderson, Jude Bellingham, Jordan Henderson, Declan Rice, Morgan Rogers, Alex Scott, Adam Wharton.
Forwards: Jarrod Bowen, Eberechi Eze, Phil Foden, Anthony Gordon, Harry Kane, Marcus Rashford, Bukayo Saka.
Weuadeopt
0
Danny Welbeck ommision is not understandable
Jeeblmprsu
0
Jude for england is worse than pini for brazil overrated scamm
is a lie
MUTAPE10
1
Gallagher ?
Zuodituyz
1
sam6602
1
Jude for england is worse than pini for brazil overrated scamm
biebcdmrs
0
where is skelly
Tuchel said Oreilly is just the best so skelly is rubish even Arteta himself is not using him,dont be stupid maan,how can they call skelly??that was just friendlys cause England was in an easy group...so these time its tough and he said he need defenders like Oreilly and Cucurella but he is from spain...ask us that watch the EPL and the skelly for last season is different from the current one that s why tuchel left him...
Voeenoprsz
0
Welbecm shall be in
ricbcelo
0
where is skelly
Maaabdely
0
Bellingham
EORR
0
Danny Welbeck should feel hard done by. In a squad with only one Striker, where the others either aren't playing, playing well, or just recovered from injury, and you're fit and performing; you still can't make it. Shame on Tuchel.
Yetaeiptu
2
Marcus rashford is a quality player 👏 🙌
ChristThompson
0
good