Benjamin Mendy has left the France squad after being diagnosed with a knee injury, while Alexandre Lacazette has also been replaced.
The French Football Federation (FFF) confirmed on Monday that Arsenal striker Lacazette has withdrawn after a consultation between national team doctor Franck Le Gall and Gunners medical staff.
The 27-year-old had only been officially added to the France squad on Monday, after Manchester United's Anthony Martial pulled out with a groin problem.
The FFF did not specify the injury to Lacazette, who has been replaced in the squad by Alassane Plea.
However, they did confirm that Manchester City full-back Mendy has suffered "a sprained left knee and a meniscal injury" and will return to his club for treatment.
Lyon defender Ferland Mendy has replaced his namesake in Didier Deschamps' set-up.
France face Netherlands in the Nations League on Friday before a friendly match with Uruguay four days later.
kaacikpt
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The World Cup just ended over this past summer- these international friendly are Pointless- I do not even watch them. Iam happy Alex lacazzette didn't even answer to the France team asking him - now that pogba and martial are unavailable- it's feels like, 'okay since these guys aren't available I guess we' lol call you Alex'. I don't think so. Why didn't France invite Lacezzette for the World Cup team? Why do they want him now? Personally these players have a lot to lose when they keep playing in these pointless friendly. Alex is essential for Arsenal for epl matches and for the Europa matches now that the team is in the round of 32 and with Welbeck being injured. What would happen to arsenals strikers if lacazzette was to play during these international friendlya and get injured? Answer is nothing- the loser would be Arsenal football club . Gunners for life, peace out