Signed in the summer from Napoli, Raspadori has struggled to make an impact so far in LaLiga.
He has been linked with a return to Serie A, where Roma and Lazio are keen.
"He continues to work with the same sense of responsibility that he has shown since he joined. The way he is training does not indicate that he is close to a move," Simeone told Marca.
"We are open to whatever may happen. We take it one thing at a time, and focus on the next game."
Raspadori has a deal with Atletico to 2030.
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Atletico Madrid
Simeone