This is the sixth match since Santiago Solari took over as Real Madrid first-team coach and it is the sixth where Isco doesn't feature in the starting line-up.
In fact, this time around he hasn't even been included on the bench and he has been left out of the final squad.
It is believed this is a sporting decision, even if it was reported that the player had a minor physical issue.
With Dani Carvajal back from injury and starting against Roma, Solari has now used 20 different players as starters, yet none of these is Isco.
It's a tough blow for the No.22, whose face said it all when he stepped off the team bus.
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Real Madrid
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are you trying to prove that without cr7 you can win cup and score goals. but still appreciate him if not Madrid will not progress.