Cremonese stunned Roma for their first Serie A victory this season to leave Welsh side Airbus UK as Europe's only top-flight team yet to win in 2022-23.
The hosts ended a joint-Serie A record of 30 games without a win dating back to 1995-96, their last season in the top flight.
Daniel Ciofani scored a late penalty to win the game for Cremonese, who climbed off the bottom of the table.
Frank Tsadjout had given them the lead before Leonardo Spinazzola's equaliser.
Roma, who also lost to Cremonese in the Coppa Italia this season, had coach Jose Mourinho sent off for dissent at the start of the second half.
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