Lazio go looking for a second consecutive victory, but Serie B title winners Empoli are on solid form too and believe in an upset.
It kicks off at the Stadio Castellani at 17.00 UK time (16.00 GMT), follow the build-up and action as it happens on the LIVEBLOG.
The Aquile had a rough start to the campaign with two unlucky defeats, but ended the slide with a hard-fought 1-0 win over Frosinone.
Valon Berisha and Luiz Felipe are out injured, but Adam Marusic has shaken off a knock to start after international duty.
It’s the usual group for Simone Inzaghi, with Lucas Leiva and Sergej Milinkovic-Savic supporting Luis Alberto and Ciro Immobile.
Empoli have a full-back shortage, as Luca Antonelli and Manuel Pasqual are unavailable, so centre-back Frederic Veseli has to adapt on the left.
Empoli: Terracciano, Di Lorenzo, Silvestre, Rasmussen, Veseli, Bennacer, Capezzi, Acquah, Zajc, Krunic, Caputo
Lazio: Strakosha, Wallace, Acerbi, Radu, Marusic, Parolo, Leiva, Milinkovic-Savic, Lulic, Luis Alberto, Immobile