Hellas Verona make their debut under new coach Eusebio Di Francesco with Nikola Kalinic upfront, while Sassuolo must do without Domenico Berardi.
It kicks off at the Stadio Bentegodi at 17.30 UK time (16.30 GMT).
You can follow the build-up and action as it happens from all four Serie A matches today on the LIVEBLOG.
Both teams are starting the season under new tacticians and Di Francesco is up against his former club as well.
Verona miss Kevin Lasagna, Marco Davide Faraoni and Kevin Ruegg, so Casale gets the nod, but new goalkeeper Lorenzo Montipò isn’t fully fit yet.
Sassuolo begin under Alessio Dionisi, but are missing their talisman Berardi, officially due to injury, but also after he requested a transfer.
Giorgios Kyriakopoulos is suspended, with Matheus Henrique, Pedro Obiang and Filippo Romagna unavailable.
Giacomo Raspadori therefore starts in a deeper role with Jeremie Boga behind Francesco Caputo.
Verona: Pandur; Dawidowicz, Günter, Ceccherini; Casale, Veloso, Hongla, Lazovic; Barak, Zaccagni; Kalinic
Verona bench: A Berardi, Montipò, Ilic, Cetin, Cancellieri, Rüegg, Magnani, Bessa, Frabotta, Ragusa, Tameze, Di Carmine
Sassuolo: Consigli; Toljan, Chiriches, Ferrari, Rogerio; Frattesi, Lopez; Raspadori, Djuricic, Boga; Caputo
Sassuolo bench: Satalino, Pegolo, Magnanelli, Ayhan, Haraslin, Peluso, Muldur, Traore, Oddei, Scamacca, Defrel