Holders Borussia Dortmund suffered a shock exit from the German Cup at the hands of second-tier St Pauli on Tuesday, going down 2-1.
Etienne Amenyido gave St Pauli a fourth-minute lead from close range and Axel Witsel's own goal in the 40th minute doubled the hosts' advantage.
Erling Haaland's penalty just before the hour mark reduced the gap but St Pauli hung on to reach the last eight.
Bundesliga side FC Cologne also went out to second-tier opposition as they lost on penalties to Hamburg SV after the tie ended 1-1.
Bochum beat Mainz 3-1 in an all-Bundesliga clash
