While the big six all play 38 Premier League games every season, the matches against their direct rivals can prove decisive.
There's still a debate whether the concept of 'the big six' is relevant, given that Leicester City and West Ham finished in the European places last season. It wouldn't be a surprise to see David Moyes' Hammers continue to upset the applecart come May.
Still, the fact remains that Manchester City, Manchester United, Liverpool, Arsenal, Chelsea and Tottenham dwarf the rest of the competition when it comes to their resources and wage bills – not to mention how their clashes are hyped up by the broadcasters.
But who has come out on top of those marquee fixtures so far this season?
As ever, Pep Guardiola's Manchester City remain imperious, while Liverpool are still unbeaten against the would-be title challengers but have found themselves drawing more often than winning.
Chelsea and United's records against the old guard are mixed, while Arsenal and Tottenham have both struggled to show up for the big occasion this season.
1. Manchester City – 20 points
Played: 10
Won: 6
Drawn: 2
Lost: 2
Goals for: 22
Goals against: 9
Goal difference: +13
2. Liverpool – 17 points
Played: 9
Won: 4
Drawn: 5
Lost: 0
Goals for: 24
Goals against: 9
Goal difference: +15
3. Chelsea – 12 points
Played: 9
Won: 3
Drawn: 3
Lost: 3
Goals for: 13
Goals against: 10
Goal difference: +3
4. Manchester United – 10 points
Played: 8
Won: 3
Drawn: 1
Lost: 4
Goals for: 11
Goals against: 20
Goal difference: -9
5. Tottenham – 7 points
Played: 8
Won: 2
Drawn: 1
Lost: 5
Goals for: 9
Goals against: 18
Goal difference: -9
6. Arsenal – 6 points
Played: 8
Won: 2
Drawn: 0
Lost: 6
Goals for: 10
Goals against: 21
Goal difference: -11