LaLiga are planning to play the league fixture between Villarreal and Atletico Madrid in Miami.
The match, which will take place on December 8, will be the first LaLiga Santander game to be played outside of Spain.
According to El Confidencial, an agreement is in place between LaLiga and both clubs to play the fixture at the Hard Rock Stadium.
"I hope this time it comes to fruition, we're starting to see if Villarreal-Atleti can be played in Miami," Villarreal president Fernando Roig told El Transistor.
"Both us and Atleti have agreed to play in Miami, but I would like this to be a consensual agreement from everyone.
"I would like there to be a consensual agreement because I think that taking LaLiga abroad would be good for everyone."
Villarreal vice-president Jose Manuel Llaneza met with LaLiga officials in Madrid on Tuesday to discuss the details of the arrangements and give it the green light.
Villarreal will refund their fans for the match as it will no longer take place at their Estadio de la Ceramica home.