Napoli are still without Victor Osimhen and coach Gennaro Gattuso could decide to play a 4-3-3 formation against AZ Alkmaar tonight.
The match kicks off at 20.00 UK time.
The Partenopei are first in Group F, but lead AZ and Real Sociedad by a mere two points ahead of the last two remaining fixtures.
A win tonight would secure them a place in the last-32 and Gattuso is expected to go all-in at the AFAS Stadion.
Osimhen is still carrying out therapy and personalised training, meaning Dries Mertens should start in the middle of the attacking trident.
Captain Lorenzo Insigne should be at left and Matteo Politano is expected at right in the attacking trident.
David Ospina could get the gloves, behind Giovanni Di Lorenzo, Nikola Maksimonvic, Kalidou Koulibaly and Faouzi Ghoulam in defence.
Fabian Ruiz, Tiemoe Bakayoko and Piotr Zielinski are tipped to start in the middle, as Napoli want revenge from the surprising 1-0 defeat at the San Paolo against a COVID-hit AZ Alkmaar.
The home side have Jordy Clasie in isolation for coronavirus this time too, but Myron Boadu should return to the attacking trident.
Jeremy Helmer is out injured and Arne Slot, seems set to give Calvin Stengs, Teun Koopmeiners and Fredrik Midtsjo the opportunity in the middle.
AZ Alkmaar (probable): Verhulst; Wijndal, Martins Indi, Chatzidiakos, Svensson; Stengs, Koopmeiners, Midtsjo; Gudmundsson, De Wit, Boadu
Napoli (probable): Ospina; Di Lorenzo, Maksimovic, Koulibaly, Ghoulam; Fabian, Bakayoko, Zielinski; Politano, Mertens, Insigne
Referee: Buquet (FRA)