Head coach Jorge Sampaoli has been sacked by Sevilla following the club's defeat at the hands of Getafe on Sunday after just five months in charge.
The loss leaves the club stuttering in 14th in a disappointing season, and hovering just two points above the relegation zone.
Were Sevilla to be relegated at the end the season, next season would mark the first time the Spanish club has played outside La Liga in 22 years.
Los Nervionenses shared a statement on Sampaoli's departure on Tuesday, reading: 'Sevilla FC has terminated the contract with its coach, Jorge Sampaoli, after the team's defeat in Getafe, which has once again placed them on the verge of relegation places.
'The fact that the team has not managed to get out of the lowest positions in the table since his incorporation as coach and the image offered in the last matches of the team have led the club to make this decision, in search of a reaction in the twelve last days that remain to finish the league.
'Sevilla FC thanks Sampaoli for the services he has provided and wishes him the best of luck in his future.'
Sevilla reportedly agreed terms with Jose Luis Mendilibar, formerly of Eibar and Alaves, before the public announcement of Sampaoli's sacking.
Mendilibar, who would take the helm until the end of the season, would be the club's third manager of the campaign.
Sampaoli was appointed at the club for his second spell in October 2022, taking over after Julen Lopetegui dismissed following a dismal start to the season that saw him oversee five losses in his final eight matches in charge in Seville.
Lopetegui was later handpicked to guide Wolves' rebuild.
The Argentine manager had previously served as the Sevilla's head coach for the 2016/17 season during which time he presided over a 40-match unbeaten run.
Sampaoli was then head-hunted by his national team, overseeing a chaotic 2018 World Cup campaign where he endured an abortive player mutiny following an uninspiring run in the group stages.
The former Chile national team coach survived the threat, but his Argentina side was later eliminated by eventual winners France.
Sevilla's new manager will have the international break before Sevilla's next two La Liga matches against 15th-placed Cadiz and Celta Vigo, who sit 10th.
In less than a month, Sevilla will travel to Old Trafford to face Manchester United in their first Europa League quarter-final tie.