Luke Shaw will undergo surgery on Saturday to remove two metal bolts that were put in his leg after it snapped in two places in 2015.
The left-back came alarmingly close to having his leg amputated following the injury he suffered against PSV Eindhoven in a Champions League game seven years ago.
The double leg fracture kept him sidelined for almost seven months and he had to a long slog back into first-team favour followed.
But speaking ahead of their Premier League fixture at Everton at the weekend, interim boss Ralf Rangnick hinted the 26-year-old was still suffering the effects of the horror injury seven years ago.
The German revealed the England international's substitution during the 1-1 draw against Leicester last weekend was a precautionary measure, and that he will now miss the next few weeks.
'Luke is still injured. We had to take him off at half-time and he's having problems with his leg where he had his operation back in 2015,' Rangnick said.
'The doctor told me they decided to remove the metal things in his leg, there are two bolts that need to be removed and that will happen tomorrow.
'He will be out for the next two or three weeks.'
Shaw joined United from Southampton in 2014 with a fast-growing reputation as the best full-back in the country, only to suffer the career-threatening injury a year later.
'I was really close to losing my leg,' the 23-year-old said back in 2018.
'I didn't know that until six months later when the doctor told me. At the time, they were thinking about flying me back [from Holland].
'If I'd flown back [to Manchester], I would probably have lost my leg because of the blood clots in the leg. I have got two scars down the side of my leg where they had to cut it open and pull the clots out.'
Shaw has also struggled on the injury front this term, often forcing Rangnick to call upon Brazilian back-up Alex Telles.
Rangnick meanwhile confirmed Cristiano Ronaldo will face the Toffees after missing the Foxes draw with an unspecified illness, but also revealed Edinson Cavani, Raphael Varane and Scott McTominay remain absent.
He said: 'Cristiano is back again. Cavani is still injured, Varane is injured and will be missing out tomorrow, the same is true for McTominay, he's having problems with the sole of his foot.'
