These sides were involved in high-scoring Europa League games midweek and Sunday's meeting should yield plenty more goals at the Commerzbank-Arena
Both teams to score landed in every Bundesliga match last weekend and the goals markets look well worth considering again on Sunday.
Eintracht Frankfurt completed an unlikely 2-1 win at Marseille in the Europa League despite being down to 10-men for most of the second half.
It's 41/20 (3.05) with 888Sport that the hosts make it back-to-back victories, but the bookies believe they'll struggle against RB Leipzig.
The visitors are just 5/4 (2.25) to win the game while a draw is 12/5 (3.40).
Leipzig rested several key players including Timo Werner for their clash with Red Bull Salzburg and were largely outplayed by their Austrian hosts in a 3-2 defeat.
Instead of trusting them in the match odds market, backing goals looks much the better option for punters.
Taking the last five games of each side in all competitions has seen both teams to score land on nine occasions. That is just 11/20 (1.55) but going over 2.5 goals at 3/4 (1.75) looks attractive at a much more enticing price.
The two defences are much too difficult to trust and given that the away side should be back to full strength, it’s tough to envisage how this game is a low-scoring one based on the recent form.
This bet has landed in eight of the last 10 RB Leipzig games in the Bundesliga and over 3.5 goals has paid out in seven of those.
That's a 39/20 (2.95) shot and looks worth a smaller stake but the main bet of at least three strikes is the main selection for what should be yet another shoot-out.
These teams have played each other four times, all since January 2017 and over 2.5 goals has landed on each occasion. To get 3/4 (1.75) on another instance here looks a very tasty opportunity.