Pep Guardiola's side will hope to cement first place in their Champions League group by picking up at least a point at the Etihad Stadium
Manchester City will hope to bounce back from their first Premier League defeat of the season in their Champions League match-up against Hoffenheim.
The Premier League champions have already secured qualification from the group but Lyon could still overtake City if Pep Guardiola's side lose at home, and the French club beat Shakhtar Donetsk.
Hoffenheim are yet to win a game in Group F and will not be holding much hope of getting a victory against City.
TV Channel, Live Stream & How To Watch
In the United States (US), the game can be watched on Univision Deportes and streamed on B/R Live
In the United Kingdom (UK), the game can be watched live on BT Sport 2 and streamed on the BT Sport app.
Squads & Team News
Claudio Bravo and Kevin De Bruyne remain unavailable for Man City. Benjamin Mendy is also sidelined whilst Sergio Aguero is a doubt.
David Silva is set to be out for three weeks with a muscular problem.
Possible Man City starting XI: Ederson, Walker, Stones, Laporte, Delph; Fernandinho, B. Silva, Gundogan; Sterling, Jesus, Sane
Hoffenheim have a whole host of players unavailable; Lukas Rupp, Nadiem Amiri, Dennis Geiger, Havard Nordtveit and David Otto are all missing whilst Adam Szalai is suspended,
Possible Hoffenheim starting XI: Baumann, Kaderabak, Vogt, Hubner, Schulz; Demirbay, Rupp, Grifo, Bittencourt, Kramaric, Belfodil
Betting & Match Odds
Unsurprisingly, City are heavily fancied for this game with bet365 making them odds-on favourites at 2/7. Hoffenheim are available at 10/1 and the draw is 11/2
Match Preview
City will be hoping to right the wrongs of Saturday night when they face Hoffenheim in their final Champions League group game.
The Premier League champions saw their hopes of an undefeated season ended as Chelsea comfortably disposed of City in a 2-0 win at Stamford Bridge.
This means they now trail Liverpool in the Premier League title race with a gap of one point to make up.
Pep Guardiola may elect to rest players in what should be a routine win against Hoffenheim as to not further worsen their injury crisis.
They have been without key man Kevin de Bruyne again recently, while David Silva has now joined the Belgium international on the sidelines.
Hoffenheim have been off the pace in the Bundesliga this season, sitting in seventh place as they chase Champions League qualification for next term.
The German side can still make the Europa League if they finish third but they need Lyon to do them a favour against Shakhtar.