With Pochettino's sacking, every side that faced Ajax in the Champions League last season now has a new manager.
Group stage opponents AEK Athens, Benfica and Bayern Munich all have new men in charge, while knock-out rivals Real Madrid, Juventus and eventual conquerors Tottenham are all now under new stewardship.
The first manager to fall was Benfica boss Rui Vitoria, leaving the club on January 4, 2019 after three and a half years in charge.
He would be followed by Marios Ouzounidis a month later, the Greek departing AEK Athens to be replaced by the returning Manolo Jimenez - only to last less than four months himself.
After a turbulent spell in charge of Real Madrid, taking over from the sacked Julen Lopetegui on October 30, Santiago Solari would then himself be replaced by Zinedine Zindane in mid-March.
When Juventus boss Massimiliano Allegri revealed he would be ending his five-year spell in Turin in May, that left just Pochettino and Niko Kovac remaining heading into the new season.
Here are the teams:
Benfica - Rui Vitoria (Jan 19)
Athens - Marinos Ouzounidis (Feb 19)
Real Madrid - Santi Solari (March 19)
Juventus - Max Allegri (May 19)
Bayern Munich - Niko Kovac (Nov 3)
Tottenham - Mauricio Pochettino (Nov 19)