Police stepped up efforts to prevent Eintracht Frankfurt fans from entering the Emirates Stadium on Thursday as they penned supports together outside the ground.
The German club have been banned by UEFA in having fans attend the Group F fixture after crowd disturbances during their away match with Vitoria Guimaraes in October.
Frankfurt were not given a ticket allocation subsequently but a large number of fans have travelled to London in an attempt to be inside the ground for the game.
Arsenal are eager to avoid a repeat of the September 2017 Europa League encounter with another German club, Cologne, which saw 20,000 visiting fans take over the stadium.
A number of Cologne fans without tickets followed Arsenal fans to the turnstiles and stormed their way in while there were clashes with police and stewards outside the Emirates.
In trying to learn from events three years ago, ticket checks were implemented on all fans at least 100 metres away from stadium entrances and more security checkpoints have been set up closer to the Emirates Stadium.
The club didn't put tickets on general sale and have shut down their official resale website so Arsenal fans cannot sell their unwanted tickets to Frankfurt fans searching for a way to be at the game.
Arsenal went further as they had to suspend their membership scheme in order to prevent any German fans signing up in the build-up to this game.
UEFA's ban stemmed from events in the stands that overshadowed their away game against Guimaraes.
Ultras fought Portuguese police in the stands, ripped out seats and used them as missiles during the match in Guimaraes on October 3.
That trouble led to fans also being banned from their away game against Standard Liege in Belgium back on November 7.
A statement published on Arsenal's website on Tuesday afternoon asked for supporters to arrive well before the 8pm kick-off because of the extra security checks.
The club spokesman said: 'The additional measures in place will be two-fold. Firstly, on approach to the turnstiles, supporters will need to show their physical ticket to stewards.
'Then at the turnstiles, stewards will make a check of the validity of the ticket to gain access.
'These measures will undoubtedly slow down entry into stadium for supporters, but if fans plan their journey and arrive in good time, we are hoping that any delays will be minimal.'