The Bluebirds gained automatic promotion last season but the latest odds suggest that Neil Warnock's men are set to go back down to the second tier.
Cardiff City are the only odds on Premier League side to go down to the Championship, according to the latest odds from bet365.
An impressive 16 homes wins helped the Bluebirds gain promotion last term, but the online bookmaker still makes them just 4/6 (1.67) to be relegated this time around.
The last time Cardiff were in the top flight was just four years ago, but that season ended in disaster as the club recorded just seven wins and slumped to finish bottom of the table.
As well, manager Neil Warnock's only previous full season in the Premier League saw Sheffield United get relegated back in 2006/07.
Meanwhile, Huddersfield Town are just 11/10 (2.10) to be relegated after surviving last season by the skin of their teeth thanks to draws at both Manchester City and Chelsea at the end of the campaign.
Fulham, who beat Aston Villa in the play-off final, are 2/1 (3.0) joint third-favourites for relegation and will hope to emulate the Terriers in surviving the top flight after winning the showpiece at Wembley.
Also available at 2/1 (3.0) are Watford, who took 15 points from their first eight games but still ended up in a relegation battle after losing 11 of their next 17 and could be in for a similar fate this year under Javi Gracia.
Similarly, Brighton can be backed at 2/1 (3.0) in the same market, whilst Burnley’s Europa League run may get the better of them and could prove a shrewd bet at 4/1 (5.0).
Available to back at 9/2 (5.50) is Bournemouth for those who believe their run in the Premier League will end after four years.
Newcastle and Crystal Palace are both priced at 5/1 (6.0), with the trio of Wolves, Southampton and West Ham all quoted at 7/1 (8.0) by bet365.