Jurgen Klopp's men host Leicester City on Wednesday night but have already seen their outright odds cut after a shock result at St James' Park
Liverpool were one of the big winners from a dramatic evening of Premier League football despite not kicking a ball.
All looked to be going to form as Sergio Aguero put Manchester City 1-0 up inside a minute against Newcastle United at St James’ Park.
City and Aguero could have had a second goal shortly afterwards but the strike was ruled out due to Kevin De Bruyne taking the free-kick before referee Paul Tierney had indicated he could do so.
The Argentina international has been a thorn in the Magpies' side throughout his time in England, scoring 15 times against them, but the home side masterminded a dramatic comeback in the second half.
Goals from Salomon Rondon and Matt Ritchie gave Rafael Benitez's side a huge win and dealt a significant blow to City's hopes of retaining their top-flight crown.
bet365's latest Premier League odds have Guardiola's men at 9/4 (3.25) (from 6/5) to end the campaign on top, while Liverpool went from 4/6 (1.67) to 4/11 (1.36).
That price is likely to fall even further if the Reds - who are 2/9 (1.18) shots - get the better of Leicester City at Anfield on Wednesday evening. Such a result would stretch their advantage at the top of the table to seven points with 14 games remaining.
Manchester City (1/5) were a similar price to win at St James' Park of course, but the quotes available on the Reds demonstrate how much faith the bookmakers have in another home win.
Punters who believe Leicester City can dent Liverpool’s title ambitions at Anfield can get 14/1 (15.0) on the Foxes coming out on top with bet365.
The Premier League has been a two-horse race for some time now with Tottenham (66/1) next in the betting while Chelsea (400/1), Manchester United (500/1) and Arsenal (750/1) are more concerned with their top four prospects as opposed to targeting top spot.
Ole Gunnar Solskjaer's winning run came to an end at Old Trafford with his side scraping a 2-2 draw against Burnley. The Red Devils are now 2/1 (3.0) from 11/8 (2.38) to finish in the Champions League places this term.