Ole Gunnar Solskjaer suffered his first defeat at Old Trafford and the bookmakers aren't optimstic about the Red Devils' chances of progression
Despite a gamble emerging on Manchester United to beat Paris Saint-Germain at Old Trafford, the money proved to be wide of the mark.
Goals from Presnel Kimpembe and Kylian Mbappe in the second half gave Thomas Tuchel's side a commanding 2-0 advantage to take back to the French capital.
United started the match at Old Trafford as 27/20 (2.35) favourites, well backed from 5/2 (3.50) when the last 16 draw was made in December.
A combination of a change of manager, much improved domestic form and injuries to key players such as Neymar and Edinson Cavani saw punters put their faith in the hosts to take a first leg advantage but to no avail.
Ole Gunnar Solskjaer lost his first game in charge as PSG became the first French club to beat the Red Devils at Old Trafford in European competition.
Previously sides from across the channel had lost 10 and drawn four of their encounters at the iconic stadium, and this was just PSG's second competitive win in England on what was their 11th match there.
None of the previous 34 teams to lose the first leg of a Champions League knockout match at home by two or more goals have progressed to the next round. With that in mind, it's unsurprising to see William Hill make United huge 20/1 (21.0) underdogs to turn the tie around.
Those siding with PSG were assured of a match odds payout when Kimpembe struck the opener thanks to William Hill's Golden Goal promotion. This sees the team who scores the first goal in selected matches paid out as the winner of the game regardless of the result after 90 minutes.
As if the task wasn't big enough from two goals down, the visitors will be without the influential Paul Pogba after the midfielder was shown a red card in the dying minutes of an ill-tempered clash. Referee Daniele Orsato handed out nine yellow cards as well as giving Pogba his marching orders.
PSG are made 11/20 (1.55) favourites to win the second leg with United priced at an industry-best 5/1 (6.0) with William Hill. A draw would be enough to secure the Ligue 1 champions a spot in the quarter-finals and that is a 7/2 (4.50) shot at the time of writing.
Having failed in their quest for European glory in previous campaigns, PSG are now 5/1 (6.0) from 13/2 (7.50) to win the Champions League while United have drifted to as big as 125/1 (126.0) in places.