There has not been an English winner of this competition since 2012, yet this season the Premier League sides lead the way in the knockout stages
The Premier League has more representation in the last 16 of the Champions League than any other division and England will be hoping to end Spain's stranglehold on Europe's major club competition.
Each of the last five winners have come from the Primera Division with Real Madrid winning four of the last five and Barcelona triumphing in the other.
Manchester City's favourable draw against Schalke in the last 16 has further reinforced their status as favourites for the competition.
However, Manchester United, Tottenham and Liverpool all face tough clashes against Paris Saint-Germain, Borussia Dortmund and Bayern Munich respectively.
Nevertheless, England remains the shortest priced nation in bet365's market for nationality of Champions League winner at 6/4 (2.50) ahead of Spain at 9/4 (3.25).
Spain's big two clubs have both been drawn against sides they would expect to defeat in the knockout stages. Real Madrid's dominance in this competition over the last few years have been extraordinary and while Los Blancos have struggled domestically they still managed to win their group, to be drawn against Ajax in the last 16.
Barcelona also finished top to be drawn against Lyon and Lionel Messi suggested at the start of the season that the Blaugrana's priority was regaining the Champions League.
Atletico Madrid - whose stadium will be hosting the final - face a tough draw against Juventus, but there should still be at least couple of Spanish sides in the quarter finals.
Italy also boast multiple representatives and while last season's semi-finalists Roma remain outsiders, Juventus feel they have an excellent chance to win their first title since 1996. The Old Lady now boast the Champions League's leading scorer in Cristiano Ronaldo and eased through to the last 16.
An Italian winner is offered at 6/1 (7.00) ahead of France at 13/2 (6.50) whose main hope has to be Paris Saint-Germain with Lyon facing an uphill assignment against Barca in the last 16.
Germany have Bayern Munich, Borussia Dortmund and Schalke left in the tournament but remain realative outsiders to provide the winner at 9/1 (10.00) with Netherlands offered at 80/1 (81.00) and Portugal at 100/1 (101.00).
Prices correct at the time of writing. Please gamble responsibly.