The Saints are searching for a new boss and the former RB Leipzig man heads the list of potential replacements according to the bookmakers
A 2-2 draw with Manchester United wasn't enough to save Mark Hughes from the sack at Southampton.
The Saints have made a disappointing start to the Premier League campaign, taking just nine points from 14 games.
That tally leaves them inside the relegation zone and the south-coast club have taken the decision to bring in a new boss in an attempt to stave off another battle against the drop.
The big market mover since the news broke has been Ralph Hasenhutti who has been backed from 33/1 (34.0) to 8/11 (1.73) favourite with William Hill.
The 51-year-old left RB Leipzig in the summer and reports suggest that the Austrian is Southampton's first choice in terms of a permanent replacement for Hughes.
“It has pretty much been one way traffic for Ralph Hassenhutl and his price has tumbled considerably in less than an hour,” said William Hill spokesman Joe Crilly.
In two years at Leipzig Hasenhutti had a 48 per cent win record and prior to that role he spent time at Ingolstadt, Aalen and Unterhaching. His high tempo approach would likely be a welcome change compared to that which has seen Southampton score just 12 times thus far.
Former Watford boss Quique Sanchez Flores had led the way initially but has since drifted to 7/1 (8.0) following a flurry of support for the new market principle.
Paolo Sousa was pictured in the stands when Southampton took on Fulham recently, prompting rumours that the former Swansea and Leicester boss would also be a contender should the job become available. The Portuguese is 6/1 (7.0) second favourite at the time of writing.
Leonardo Jardim is available at 14/1 (15.0) with 20/1 (21.0) the price about Sam Allardyce making a return to the Premier League.
The former Everton and West Ham boss is often heavily linked with jobs where avoiding relegation is the primary objective but the prices suggest Southampton are looking away from the usual candidates such as Allardyce, David Moyes (33/1) and Alan Pardew (25/1).
Kelvin Davies will take charge of the match against Tottenham on Wednesday but at 25/1 (26.0) he's seen as an unlikely candidate for the full-time role.
William Hill make the Saints 10/3 (4.33) to be relegated this season and 8/1 (9.0) to leave Wembley with three points when they face Spurs.
With Southampton facing a crunch clash against Cardiff City at the weekend, a swift apppointment may be on the cards and Hasenhutti is certainly the frontrunner according to the odds compilers.