Arsenal will welcome Bayern Munich and former Tottenham striker Harry Kane in the Champions League quarter-finals, while holders Man City face Real Madrid in a blockbuster tie.
The Gunners will host the reigning German champions in the first leg at Emirates Stadium on April 9, before travelling to the Allianz Arena on April 17.
Pep Guardiola's quest for a second consecutive Treble will require Man City to overcome record Champions League winners Real Madrid in the quarter-finals.
City face Real in Spain on April 9, with the return leg to take place in England on April 17.
An all-English semi-final is possible with the winners of Arsenal and Bayern Munich hosting the victors of the tie between Man City and Real Madrid in the first leg of the semi-finals.
The quarter-final line-up also sees Paris Saint-Germain and Barcelona clash, with the winners meeting either Atletico Madrid or Borussia Dortmund.
Arsenal will have to overcome a miserable head-to-head record against Bayern in Europe’s elite competition.
Bayern have won seven of their meetings in the competition to the Gunners' three, while there have been two draws between the sides.
The German champions have won their last three matches 5-1 against Arsenal in the competition, winning 10-2 over two legs in the last-16 back in the 2016-17 season.
Bayern have won all four Champions League knockout ties with the Gunners.
Kane's return to North London will add further intrigue with Tottenham's record goalscorer having scored 14 goals in 19 matches against their fiercest rivals.
Manchester City and Real Madrid will meet for the third consecutive season in the knockout stage, but this time in the last eight.
Guardiola's side will be hoping for a repeat of last year's semi-final where a 4-0 home win too the Citizens into the final, after drawing the first leg 1-1.
Real Madrid had beaten City in a thrilling semi-final the previous year, winning 6-5 on aggregate.
Barcelona and PSG will renew their rivalry in the competition, with their tie bringing back memories of the Catalan giants' famous comeback in the 2016-17 season. The first leg will be played in France on April 10, with the second leg to take place in Spain on April 16.
Lionel Messi and Co memorably fought back from a 4-0 first leg defeat by winning the return fixture 6-1 in the last-16 tie.
PSG, however, emerged as 5-2 winners on aggregate in their previous meeting in the competition at the same stage back in 2020-21.
Dortmund and Atletico Madrid have meet six times, with their most recent matches coming in the 2018-19 group stage. Atletico will host the first leg on April 10 before the return game in Germany on April 16.
Jadon Sancho was on target as Dortmund won 4-0 in Germany, before Atletico won their home match 2-0.
The quarter-final first legs will take place on April 9 and 10, with the return fixtures held a week later on April 16 and 17.
Semi-final first legs will be held on April 30 and May 1, with the finalists known after the second legs on May 7 and 8.
Wembley will host the final on June 1.