Richard Keogh suffered a suspected fractured wrist and injured his knee after being involved in a car collision which saw two of his Derby team-mates charged with drink driving.
The Derby captain was reportedly in the back seat of Tom Lawrence's Range Rover which crashed into a lamppost and subsequently led to his injuries late on Tuesday night.
Team-mates Lawrence and Mason Bennett were both charged with drink-driving following an incident on the A6 in Derby.
The Daily Telegraph claim the injury will be confirmed by Derby head coach Phillip Cocu during his weekly press conference ahead of the Championship side's clash with Birmingham.
The incident occurred after a planned squad night out which was given the green light by the club.
Derbyshire police said on Tuesday: 'Two men have been charged with drink driving after a collision involving a Range Rover Sport and a Mercedes GLC at the junction of Burley Hill and the A6 at Allestree, last night shortly before midnight (Tuesday, 24 September).
'Mason Bennett, 23, of Whaley Thorns near Mansfield and Tom Lawrence, 25, of Duffield were arrested at the scene and charged earlier today. They are due to appear at Southern Derbyshire Magistrates Court on Tuesday, 15 October at 9.30am.'
Keogh has been ever present for the Rams in the league this season, playing every minute of their eight Championship fixtures.
Lawrence, a winger who has won 20 caps for Wales, has started all but one of Derby's Championship games so far this season.
Forward Bennett, meanwhile, has made six appearances for Cocu's side this campaign. In 2011, he became the club's youngest ever player when he made his debut at 15 years and 99 days old.
The Rams are currently 18th in the Championship but will receive a boost in January when Manchester United and England legend Wayne Rooney arrives as a player-coach.