Gabriel Jesus will miss the rest of Brazil's World Cup campaign with a knee injury and is a doubt for the Premier League restart with Arsenal later this month.
The striker picked up the injury during Friday's 1-0 defeat against Cameroon and came off in the 64th minute.
Left-back Alex Telles, who also limped off injured in Brazil's final Group G match with a right knee problem, has also been ruled out of the tournament.
A statement from the Brazilian FA read: "As announced by the Brazilian FA after the game against Cameroon, players Alex Telles and Gabriel Jesus underwent tests on Saturday morning. Accompanied by the Brazilian National Team doctor, Rodrigo Lasmar, they underwent an MRI on the right knee that confirmed the injuries and the impossibility of recovery in time to participate in the FIFA World Cup Qatar 2022.
"The coordinator of the Brazilian National Team, Juninho Paulista, is in contact with the sports directors of Arsenal and Sevilla to define whether Alex Telles and Gabriel Jesus remain with the squad in Doha to continue the treatment or return to their clubs."
Brazil are already sweating over the fitness of Neymar, who has missed their last two matches with an ankle problem.
The news is a problem for Mikel Arteta's Arsenal, who restart their Premier League campaign on Boxing Day when they host West Ham.
Jesus is the second Arsenal player to prematurely leave his World Cup squad, as defender Ben White left England's group in Qatar due to "personal reasons".
More to follow.
Brazil's potential route to the World Cup final
Monday November 5
Brazil vs South Korea - Kick-off 7pm
Friday December 9
Japan or Croatia vs Brazil or South Korea - Kick-off 3pm
Tuesday December 13
Netherlands/USA/Argentina/Australia vs Japan/Croatia/Brazil/South Korea - Kick-off 7pm
Arsenal's next fixtures
December 26 - West Ham (H), Premier League - kick-off 8pm
December 31 - Brighton (A), Premier League - kick-off 5.30pm - live on Sky Sports
January 3 - Newcastle (H), Premier League, kick-off 7.45pm - live on Sky Sports
January 9 - Oxford United (A), FA Cup third round, kick-off 8pm
January 15 - Tottenham (A), Premier League, kick-off 4.30pm - live on Sky Sports
January 22 - Manchester United (H), Premier League, kick-off 4.30pm - live on Sky Sports