Manchester City defenders John Stones and Kyle Walker will both miss Tuesday's Champions League opener at Sevilla through injury, manager Pep Guardiola has confirmed.
Neither player was included in City's travelling squad for the Group G clash at the Roman Sanchez Pizjuan Stadium.
Right-back Walker limped off in the latter stages of Saturday's Premier League draw at Aston Villa while Stones has also picked up a knock.
Guardiola said at a press conference reported by the club: "(They are) injured. John is not much. Kyle is not much too, but I don't know if he will be ready for Saturday, or Dortmund or Wolves before the international break."
City are also still without another defender in Aymeric Laporte, who has a knee problem.
It is anticipated that Laporte could be back in action after the international break.
As well as Sevilla, City will also face Borussia Dortmund and Copenhagen in Group C of the Champions League.
City are seeking to win the Champions League for the first time having reached the semi-finals in last season's competition.