The striker pulled level with Emmanuel Adebayor and Bobby Smith for most goals scored in the fixture thanks to a first-half penalty
Harry Kane has scored his 10th goal in the North London derby, equalling the record for most scored in matches between Arsenal and Tottenham.
The England international was the benificary as team-mate Son Hueng-min was fouled in the area by Gunners midfielder Granit Xhaka late in the first half with Spurs already leading 1-0.
Kane stepped up to take the penalty and slammed home a confident finish, sending Arsenal goalkeeper Bernd Leno the wrong way much to the disappointment of the Gunners faithful at the Emirates Stadium.
In doing so, Kane brought himself level with the Emmanuel Adebayor and Bobby Smith with 10 each in fixtures between the two London rivals.
The late Smith starred for Spurs between 1955 and 1964, scoring 176 times in 271 games for the club.
Adebayor is among the few people to have scored for both sides of the derby, netting eight times for Arsenal and twice for Spurs.
Kane does hold the goals record for the Premier League fixtures between the two clubs, as all 10 of his tallies came in the English top-flight. Adebayor scored two of his 10 goals in cup matches between the teams.
The England striker has enjoyed plenty of success against Arsenal of late, having scored in his last four Premier League matches against the Gunners.