Pep Guardiola's men are looking to end a three-game winless run by securing the victory at the Etihad Stadium
Manchester City will be determined to return to the top of the Premier League by picking up three points against Brighton on Wednesday.
Pep Guardiola's men cannot afford a slip-up at this stage in the race for the top-flight title with Liverpool breathing down their necks, with Jurgen Klopp's side having beaten Manchester United 4-0 on Tuesday to go top, albeit potentially for just 24 hours.
The Premier League champions have had an intense few weeks, though, and have not won any of their last three matches, having drawn with Liverpool and Atletico Madrid before losing to the Reds in the FA Cup semi-finals.
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Manchester City vs Brighton latest odds
Manchester City are heavy favourites to win the Premier League match at the Etihad Stadium, with bet365 pricing them at 1/6 (1.17).
Brighton are the big outsiders at 16/1 (17.0) to get the win, while the draw is priced at 6/1 (7.0).
Manchester City vs Brighton first goalscorer
Gabriel Jesus, Kevin De Bruyne, Phil Foden, Raheem Sterling and Riyad Mahrez are all priced at 9/2 (5.5) to score the game's first goal, while team-mates Jack Grealish and Bernardo Silva are available at 11/2 (6.5).
Neal Maupay is the lowest-priced Brighton player to get the first goal at 14/1 (15.0).
Manchester City vs Brighton preview
Manchester City could be without Kyle Walker, while Cole Palmer is still out with an ankle problem.
Kevin De Bruyne and Ilkay Gundogan could be back in the starting XI after making the bench against Liverpool at the weekend.
While Guardiola's side have suffered a dip in form by going three games without a win in all competitions, their opponents have had an improvement recently.
After taking just one point from seven games in a row, Brighton have now won two and drawn one across their last three matches.
However, Yves Bissouma is suspended for the visitors after picking up a yellow card in Saturday's 1-0 win at Tottenham.
Plus, Jakub Moder is still out with an anterior cruciate ligament injury. Shane Duffy is missing because of a thigh problem and Steven Alzate is a doubt after missing the game at Tottenham due to illness.
Manchester City vs Brighton tips & predictions
City are such huge favourites that it is only worth backing them with a handicap in this match. A handicap of -2 goals is set at 7/5 (2.4) while the safer option of -1 is 4/7 (1.57).
Alternatively, as City should dominate the whole match, betting on them to be winning at half-time and full-time is 4/6 (1.67).