The two sides played out a 2-2 draw in the Premier League last week but hope to secure a place in the FA Cup final this time around
Liverpool can keep their hopes of winning the quadruple alive when they beet Manchester City in the semi-finals of the FA Cup on Saturday.
The two sides played out a 2-2 draw in the Premier League last week, but now must fight for place in the ultimate showdown at Wembley next week.
Ahead of the game, GOAL brings you everything you need to know, including how to watch, team news, odds and more.
Manchester City vs Liverpool TV channel, live stream & how to watch
BBC One is showing Manchester City vs Liverpool live on TV in the United Kingdom (UK) and the game can also be streamed live online using BBC iPlayer.
Man City team news & squad
Kevin De Bruyne and Kyle Walker are both doubts for this match, but City have no further issues to contend with.
Predicted Man City starting XI: Ederson, Cancelo, Stones, Ake, Laporte, Silva, Rodri, Gundogan, Jesus, Sterling, Grealish
Liverpool team news & squad
Mohamed Salah and Diogo Jota are struggling with injury concerns but could still feature at Wembley.
Predicted Liverpool starting XI: Alisson, Alexander-Arnold, Matip, Van Dijk, Robertson, Henderson, Fabinho, Thiago, Salah, Firmino, Mane
Betting odds & tips
Manchester City is favourite to beat Liverpool at 8/5 (2.6) with bet365. At 7/4 (2.75) to win, Liverpool are considered slight underdogs.
Mohamed Salah is 5/1 (6.0) to be first goalscorer, while Diogo Jota is rated 6/1 (7.0).
These two teams are in excellent form heading into this clash.
Liverpool are looking to claim a quadruple of trophies, while their opponents are aiming for the treble.
Only one point separates them domestically, but City are in the best of form, as they remain unbeaten in 10 matches in all competitions.
Liverpool, meanwhile, have won five and drawn two of their last seven games.