After a disappointing defeat to Young Boys in the opening group game, Manchester United will need to do something they've never done before in order to get their Champions League campaign back on track, and that is defeat Villarreal.
In four Champions League matches against the Spanish club, there hasn't been a single goal scored by either side, with 0-0 having been the result in every single encounter.
Unai Emery's side have been in good form of late, although they opened their continental campaign with a 2-2 draw against free-scoring Atalanta.
Villarreal are confident after comprehensively outplaying Real Madrid at the weekend and there is a sense that Manchester United's frailties are there to be capitalised on, especially with Luke Shaw, Harry Maguire and Aaron Wan-Bissaka all out through injury and suspension respectively.
Yeremi Pino comes into the match in fine form after having given Nacho Fernandez nightmares in their LaLiga Santander clash, and he could be directly up against Alex Telles, who has played just one match since last season.
Manchester United vs Villarreal: Predicted line-ups
Manchester United's predicted line-up: David de Gea; Diogo Dalot, Raphael Varane, Victor Lindelof, Alex Telles; Scott McTominay, Fred, Bruno Fernandes; Mason Greenwood, Cristiano Ronaldo, Paul Pogba.
Villarreal's starting line-up: Geronimo Rulli; Juan Foyth, Raul Albiol, Pau Torres, Alfonso Pedraza; Etienne Capoue, Manu Trigueros, Dani Parejo; Yeremi Pino, Paco Alcacer, Arnaut Danjuma.
When does Manchester United vs Villarreal start?
This Wednesday's match between Manchester United and Villarreal kicks off at 20:00 local time (BST). For those living in the USA you can tune in at 15:00 ET/12:00 PT and for those living in Spain, you can tune in at 21:00 CEST.
Where to watch Manchester United vs Villarreal?
The Champions League clash between Manchester United and Villarreal will take place at Old Trafford on Wednesday, September 29.
For those living in the USA, you can watch Manchester United vs Villarreal on Paramount+. In the UK the match will be shown on BT Sport.