Messi, Vidal and Coutinho will miss Barcelona's Gamper Trophy game against Arsenal on Sunday, according to Mundo Deportivo.
It is understood that the trio, who all played to the final stage of the Copa America this summer, will return to Barcelona before Sunday's game.
However, they will not play against Arsenal because they haven't been training with the squad for a while.
Barcelona host Arsenal in Joan Gamper Trophy at 20:00 CET on August 4th, Sunday.