Isco and Marcelo may return to Real Madrid's starting line-up ahead of their last 16 Copa del Rey second leg away to Leganes.
Santiago Solari will go back to a four-man defence, and Dani Ceballos is also expected to start following his game-winning free-kick against Real Betis on Sunday.
Sergio Ramos will be given a rest, along with Karim Benzema, who is set to have an operation on Sunday, after the Sevilla game on Satuday, having fractured his finger in the match with Betis.
The probable Real Madrid XI is as follows: Keylor Navas; Alvaro Odriozola, Raphael Varane, Nacho, Marcelo; Fede Valverde, Casemiro, Dani Ceballos; Lucas Vazquez, Vinicius Jr and Isco.
On the bench: Luca Zidane, Javi Sanchez, Dani Carvajal, Sergio Reguilon, Luka Modric, Brahim Diaz and Cristo Gonzalez.
The probable Leganes XI is as follows: Ivan Cuellar, Juanfran Moreno, Unai Bustinza, Rodrigo Tarin, Dimitrios Siovas, Vasyl Kravets; Jose Luis Garcia Recio, Gerard Gumbau, Javier Eraso; Sabin Merino and Martin Braithwaite.
On the bench: David Tejero, Allan Nyom, Kenneth Omeruo, Jonathan Silva, Mikel Vesga, Jose Arnaiz and Youssef En-Nesyri.
The referee will be Martinez Munuera.