Callum Hudson-Odoi scored twice as Nottingham Forest secured a monumental 3-1 victory over already-relegated Sheffield United at Bramall Lane.
Ben Brereton Diaz's first-half penalty had increased the pressure on Nuno Espirito Santo's side in their battle to preserve their Premier League status (17), but two superb interventions from Hudson-Odoi ensure they remain in the driving seat and in control of their top-flight destiny.
The former Chelsea winger curled in a superb equaliser before the break (27) and put the game to bed with his second (65) after Ryan Yates' first Premier League goal had put Forest in front (51).
With Luton Town missing the chance to move above them following their 1-1 draw at home to Everton on Friday Night Football, it means Forest - with a far superior goal difference - can virtually secure their safety with another victory over Chelsea next weekend.
Sheffield United had Anel Ahmedhodzic sent off for a second bookable offence in the sixth minute of stoppage time after a flailing arm in a challenge with Nicolas Dominguez.
They remain bottom on 16 points and have now conceded 100 goals this season, joining Swindon Town as the only two clubs to achieve that unwanted statistic in Premier League history - and they still have two more games to set the record outright.
How Forest stayed in control of their own destiny
What a time for Forest to collect their first win in five. How they needed this. This was another punishing afternoon for Sheffield United in the Premier League - but the first half was a captivating watch.
Chris Wilder's side were deserving of their lead when a poor challenge by Gonzalo Montiel on Brereton Diaz allowed the on-loan striker to dust himself down and convert his spot-kick for his sixth goal of the season.
The response from Forest was an impressive one as Hudson-Odoi curled in a cracker to restore parity.
Chris Wood slammed a header against the crossbar from Morgan Gibbs-White's cross but the Blades had the better of the opening 45 minutes.
Cameron Archer missed two glorious chances as first Matz Sels saved at his feet before the striker scuffed a close-range effort into the ground and over the bar.
Sels was also at full stretch to deny Gustavo Hamer's long-range shot while Murillo's last-ditch challenge denied Brereton Diaz a second.
But, just as in the recent 4-1 home loss to Burnley, Sheffield United were punished for their profligacy - and fell behind just six minutes after the restart.
Yates was in the right place to fire Willy Boly's knockdown past Wes Foderingham. It survived a VAR appeal with Brereton Diaz claiming he was fouled by Murillo in the build-up.
Gustavo Hamer dragged a shot just wide as United came within inches of an instant response before Hudson-Odoi clipped the outside of the post with a trademark run and shot.
It was a warning the hosts would not heed as in almost the same position not long after, Hudson-Odoi was picked out by Gibbs-White and this time cut inside to find the bottom corner.
By now, the hosts looked a beaten outfit as Wood's clever flick was tipped around the post by Foderingham from another inviting Gibbs-White delivery. As six minutes of stoppage time had almost elapsed, Ahmedhodzic rose to catch Dominguez with the point of his elbow to compound another miserable afternoon for the Blades.
Forest are in control of their own destiny with two games remaining.
Merson: I'd be shocked now if Forest go down
Paul Merson on Soccer Saturday:
"I'd be shocked now if Forest went down. Luton need at least four points without Forest getting anything. If Sheffield United had taken their chances today, they could have been three or 4-1 up.
"They didn't take them which was the story as well against Burnley. They missed chance after chance against Newcastle as well.
"I know it's Sheffield United, they get beat a lot and they've conceded 100 goals but when you've only won twice away from home all season, it's a difficult game still. They came through it well having gone 1-0 down so fair play to them."
Forest end long wait for away win - Opta stats
Player of the match - Callum Hudson-Odoi
Paul Merson on Soccer Saturday:
"Callum Hudson-Odoi got two very good goals. The thing that disappoints me is that even I know he's coming back onto his right foot. If I know that, surely Bogle knows he's going to do it. That disappoints me and as a manager, you're thinking you've worked all week on showing him down the line.
"The first one is an unbelievable finish but he'd done exactly the same thing two minutes before he scored his second. How many times do you have to be told?
"That's why Sheffield United are where they are and that's why they've let in 100 goals. They don't take the information on. It's poor at the highest level."
What's next?
Sheffield United visit Everton on Saturday May 11, kick-off 3pm, before playing their last Premier League fixture for at least a season at home to Tottenham on Sunday May 19, kick-off 4pm.
Nottingham Forest continue their survival mission at home to Chelsea on May 11, live on Sky Sports. Kick-off 5.30pm. Forest then travel to relegation rivals Burnley on the final day on May 19, kick-off 4pm.
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